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KMID : 0383419680090020227
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Korean Modern Medical Journal
1968 Volume.9 No. 2 p.227 ~ p.239
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Studies on the bactericidal activity of immune sera against enteric bacilli
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Abstract
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The bactericidal activity of sera from rabbits immunized with formalin- treated ntigens of enteric bacilli was compared with that of normal rabbit serum under various conditions, and thei ollowing results were obtained.
At high concentrations the bactericidal powe of immune sera appeared significantly ´and ifically reduced compared with that of normal serum so far as the test. organisms were form.
1. At lower concentrations, however, a gradual increment of bactericidal activity was observed in immune sera when sufficient amount of complement was supplied.
2. A moderate reduction of agglutination titer of immune sera by absorption reaction with heat- killed homologous cells brought about a limited recovery of the bactericidal activity, whereas a complete absorption reaction rather suppressed the activity.
3. Soluble substances from the bacterial cell seemed to interfere significantly with the function bactericidal agents iri serum, reducing otherwise highly bactericidal action of absorbed serum.
4. The maintenance of a certain degree of bactericidal activity in completely absorbed sera, regardless of the absence of complement and immune bodies, may be due to the lower avidity of natural antibody or to the existence of some unknown bacteridal facto like an unabsorbable 4 bactericidal antibody in the absorbed immune sera.
5. Salmonella thompson was found to be highly resistant to the bactericidal activity of both immune and normal serum while R-form of test organisms turned out to be extremely fragile.
6. Immune body exhibited a similar bactericidal power to natural antibody when present only in such a small amount as that of natural antibody in normal serum.
7. The common properties between natural antibody and properdin and´ their origins were "thoroughly discussed and it was proposed that no differentiation was necessary so far as the serum bactericidal activity was concerned.
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